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Response to Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase"
Park et al . question one out of seven findings from Hadzipasic et al .: whether TPX2 allosterically regulates the oldest Aurora. We had already addressed the ...
Fire and biodiversity in the Anthropocene
Fire has been a source of global biodiversity for millions of years. However, interactions with anthropogenic drivers such as climate change, land use, and ...
Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase"
Hadzipasic et al . (Reports, 21 February 2020, p. 912) used ancestral sequence reconstruction to identify historical sequence substitutions that putatively ...
Architecture of the photosynthetic complex from a green sulfur bacterium
The photosynthetic apparatus of green sulfur bacteria (GSB) contains a peripheral antenna chlorosome, light-harvesting Fenna-Matthews-Olson proteins (FMO), and ...
Divergent impacts of warming weather on wildlife disease risk across climates
Disease outbreaks among wildlife have surged in recent decades alongside climate change, although it remains unclear how climate change alters disease dynamics ...
Technology Feature | Can patients' gut microbes help fight cancer?
Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations
The drivers and patterns of zoonotic virus emergence in the human population are poorly understood. The mosquito Aedes aegypti is a major arbovirus vector ...
Tissue topography steers migrating Drosophila border cells
Moving cells can sense and respond to physical features of the microenvironment; however, in vivo, the significance of tissue topography is mostly unknown. ...
Experimental observation of the liquid-liquid transition in bulk supercooled water under pressure
We prepared bulk samples of supercooled liquid water under pressure by isochoric heating of high-density amorphous ice to temperatures of 205 ± 10 kelvin, ...
A marine microbiome antifungal targets urgent-threat drug-resistant fungi
New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Candida ...
An extremely metal-deficient globular cluster in the Andromeda Galaxy
Globular clusters (GCs) are dense, gravitationally bound systems of thousands to millions of stars. They are preferentially associated with the oldest ...
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
Neurodegeneration in Alzheimer’s disease (AD) is closely associated with the accumulation of pathologic tau aggregates in the form of neurofibrillary ...
Gene regulatory networks controlling vertebrate retinal regeneration
Injury induces retinal Mu&;ller glia of certain cold-blooded vertebrates, but not those of mammals, to regenerate neurons. To identify gene regulatory networks ...
Rotavirus induces intercellular calcium waves through ADP signaling
Rotavirus causes severe diarrheal disease in children by broadly dysregulating intestinal homeostasis. However, the underlying mechanism(s) of ...
Should I stay or should I go?
Sponsored Collection | The Human Protein Atlas: A 20-year journey into the body
Oceanic plateau of the Hawaiian mantle plume head subducted to the uppermost lower mantle
The Hawaiian-Emperor seamount chain that includes the Hawaiian volcanoes was created by the Hawaiian mantle plume. Although the mantle plume hypothesis ...
Transferring allergies in the womb
China set to bring back rocks from the Moon
Artificial multimodal receptors based on ion relaxation dynamics
Human skin has different types of tactile receptors that can distinguish various mechanical stimuli from temperature. We present a deformable artificial ...
Control of long-distance motion of single molecules on a surface
Spatial control over molecular movement is typically limited because motion at the atomic scale follows stochastic processes. We used scanning tunneling ...
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
Efficient therapeutic options are needed to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused more than ...
Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE
Mast cells (MCs) are central effector cells in allergic reactions that are often mediated by immunoglobulin E (IgE). Allergies commonly start at an early age, ...
A human tissue screen identifies a regulator of ER secretion as a brain-size determinant
Loss-of-function (LOF) screens provide a powerful approach to identify regulators in biological processes. Pioneered in laboratory animals, LOF screens of ...
Redirecting a wasp's sting
A crystallographic conundrum
How RAS mutations really work
Too bright to breed
Distinct dendritic cell responses
A soft touch
Feeling temperature and touch
Cells and the path of least resistance
Unlocking retinal regeneration in mice
Climate change alters disease risks
Two ways to get tangled?
Green to the core
Riding the calcium waves
Tackling other infectious diseases
Domesticating Zika virus
A relic star cluster under the floor
Liquid-liquid transitions under pressure
Functional screen for microcephaly genes
PBT2 pumps up polymyxins
Engineering near-infrared vision
Brain mapping, from molecules to networks
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